Transcription factor regulation by mechanical stress

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

Transcriptional Regulation by Competing Transcription Factor Modules

Gene regulatory networks lie at the heart of cellular computation. In these networks, intracellular and extracellular signals are integrated by transcription factors, which control the expression of transcription units by binding to cis-regulatory regions on the DNA. The designs of both eukaryotic and prokaryotic cis-regulatory regions are usually highly complex. They frequently consist of both...

Regulation of transcription factor function by proteolysis.

67 Kyriakis, J. M. et al. (1996) Nature (London) 380, 75-79 Zanke, B. W., Boudreau, K., Rubie, E., Winnett, E., Tibbles, L. A., Zon, L., Kyriakis, J., Liu, F. F. and Woodgett, J. R. (1996) Curr. Biol. 6, 606-613 McCarthy, S. A., Samuels, M. L., Pritchard, C. A., Abraham, J. A. and McMahon, M. (1995) Genes Dev. 9, 1953-1964 68 Nishima, H., Fischer, K. D., Radvanyi, L., Shahinian, A., Hakem, R., ...

Regulation of human thioltransferase (hTTase) gene by AP-1 transcription factor under oxidative stress.

PURPOSE To study the mechanism of activation of the human thioltransferase (hTTase) gene under oxidative stress. METHODS Human lens epithelial cells (HLE-B3) were exposed to 0.1 mM H2O2 for 0, 5, 10, 15, 30, or 60 minutes; lysed; and used for gel mobility shift assay (GMSA) and supershift assay for activating protein (AP)-1 transcription factor. The search for transcriptional coactivators was...

Conserved and Distinct Modes of CREB/ATF Transcription Factor Regulation by PP2A/B56γ and Genotoxic Stress

Activating transcription factor 1 (ATF1) and the closely related proteins CREB (cyclic AMP resonse element binding protein) and CREM (cyclic AMP response element modulator) constitute a subfamily of bZIP transcription factors that play critical roles in the regulation of cellular growth, metabolism, and survival. Previous studies demonstrated that CREB is phosphorylated on a cluster of conserve...